Increased angiotensin II receptor binding with age in isolated rat glomeruli
نویسندگان
چکیده
منابع مشابه
Angiotensin II receptor internalization and signaling in isolated rat hepatocytes.
Since angiotensin II (Ang II)-induced receptor internalization is required to maintain the production of certain intracellular signals in some target cells, we investigated the relationships between Ang II receptor endocytosis and the generation of second messengers in rat hepatocytes. The results of the present study demonstrate that in response to exposure of hepatocytes to Ang II, a decrease...
متن کاملDopamine attenuates the contractile response to angiotensin II in isolated rat glomeruli and cultured mesangial cells.
Recent evidence suggests that dopamine may alter kidney function by actions not only in the renal vasculature but also at the glomerular-mesangial level. We studied this phenomenon by examining the ability of dopamine to antagonize the contractile properties of angiotensin II in isolated rat glomeruli and cultured mesangial cells. In isolated rat glomeruli angiotensin II caused a decrease in th...
متن کاملProstaglandin synthesis in isolated rat kidney glomeruli.
Isolated rat kidney glomeruli converted octatritiated arachidonic acid to several prostaglandins whose production was inhibited by meclofenamate. These were, in order of decreasing abundance, prostaglandin F2 alpha, prostaglandin E2, 6-oxo-prostaglandin F1 alpha, thromboxane B2, and prostaglandin D2. These products were identified by thin-layer chromatography, before and after treatment with po...
متن کاملAngiotensin II has acute effects on TRPC6 channels in podocytes of freshly isolated glomeruli
A key role for podocytes in the pathogenesis of proteinuric renal diseases has been established. Angiotensin II causes depolarization and increased intracellular calcium concentration in podocytes; members of the cation TRPC channels family, particularly TRPC6, are proposed as proteins responsible for calcium flux. Angiotensin II evokes calcium transient through TRPC channels and mutations in t...
متن کاملAngiotensin I is largely converted to angiotensin (1-7) and angiotensin (2-10) by isolated rat glomeruli.
Intraglomerular renin-angiotensin system enzyme activities have been examined previously using glomerular lysates and immune-based assays. However, preparation of glomerular extracts compromises the integrity of their anatomic architecture. In addition, antibody-based assays focus on angiotensin (Ang) II detection, ignoring the generation of other Ang I-derived metabolites, some of which may cr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Kidney International
سال: 1988
ISSN: 0085-2538
DOI: 10.1038/ki.1988.171